SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL PREPARATIONS BY RATIO SPECTRA DERIVATIVE METHOD

Background: As it is known, antihypertensive drugs are frequently used for the treatment of individuals with high blood pressure all over world. This study aims to precisely determine active substances telmisartan and hydrochlorothiazide, which commercially sold as in market, use ratio spectrum method this purpose. Method: All, solutions ingredients studied were prepared various concentrations. Subsequently, mixtures accordance commercial drug sample, their spectra taken by spectrophotometric method, was successfully applied these data sets. Results: The revealed that application first-order derivative yielded highly reliable outcomes analysis different combinations hydrochlorothiazide. Conclusion: can be field development. Peer Review History: Received: 25 February 2023; Revised: 8 March; Accepted: 13 April 2023, Available online: 15 May 2023 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University Alexandria, Egypt, [email protected] Received file: Reviewer's Comments: Average review marks at initial stage: 5.0/10 publication 7.0/10 Reviewers: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected] Wafa Mohamed Al Madhagi, Sana’a Yemen, [email protected]